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GF39 Anti-HGF (Scatter Factor) (Ab-1) Mouse mAb (4C12.1)

Anti-HGF (Scatter Factor) (Ab-1), mouse monoclonal, clone 4C12.1, recognizes the ~82 kDa hepatocyte growth factor in macrophages, endothelial & Kupffer cells. It is validated for use in WB & IP.

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Synonyme: Anti-Scatter Factor, Anti-Hepatocyte Growth Factor, Anti-SF, Anti-Hepatopoeitin A

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GF39
  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HMMonoclonal Antibody
      Description
      OverviewRecognizes the ~82 kDa hepatocyte growth factor protein in macrophages, endothelial, and Kupffer cells.
      Catalogue NumberGF39
      Brand Family Calbiochem®
      SynonymsAnti-Scatter Factor, Anti-Hepatocyte Growth Factor, Anti-SF, Anti-Hepatopoeitin A
      References
      ReferencesToi, M., et al. 1998. Clin. Cancer Res. 4, 659.
      Bardelli, A. and Comoglio, P.M. 1997. Ciba Found. Symp. 212, 133.
      Birchmeier, C., et al. 1997. Ciba Found. Symp. 212, 16.
      Jiang, W.G. and Hiscox, S. 1997. Histol. Histopathol. 12, 537.
      Matsumoto, K. and Nakamura, T. 1997. Ciba Found. Symp. 212, 198.
      Rosen, E.M., et al. 1997. Ciba Found. Symp. 212, 215.
      Vande Woude, G.F., et al. 1997. Ciba Found Symp. 212, 119.
      Product Information
      FormLiquid
      FormulationIn 10 mM PBS, 0.2% BSA, pH 7.4.
      Positive controlEndothelial cells, Kupffer cells, or macrophages
      Preservative≤0.1% sodium azide
      Quality SegmentMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunoprecipitation
      Application NotesImmunoblotting (1:200-1:400)
      Immunoprecipitation (10 µl/mg protein lysate)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenrecombinant, human HGF protein
      ImmunogenHuman
      Clone4C12.1
      HostMouse
      IsotypeIgG2b
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage if desired. Avoid freeze/thaw.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      GF39 0

      Documentation

      Anti-HGF (Scatter Factor) (Ab-1) Mouse mAb (4C12.1) SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-HGF (Scatter Factor) (Ab-1) Mouse mAb (4C12.1) Analysenzertifikate

      TitelChargennummer
      GF39

      Literatur

      Übersicht
      Toi, M., et al. 1998. Clin. Cancer Res. 4, 659.
      Bardelli, A. and Comoglio, P.M. 1997. Ciba Found. Symp. 212, 133.
      Birchmeier, C., et al. 1997. Ciba Found. Symp. 212, 16.
      Jiang, W.G. and Hiscox, S. 1997. Histol. Histopathol. 12, 537.
      Matsumoto, K. and Nakamura, T. 1997. Ciba Found. Symp. 212, 198.
      Rosen, E.M., et al. 1997. Ciba Found. Symp. 212, 215.
      Vande Woude, G.F., et al. 1997. Ciba Found Symp. 212, 119.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2007 RFH
      SynonymsAnti-Scatter Factor, Anti-Hepatocyte Growth Factor, Anti-SF, Anti-Hepatopoeitin A
      ApplicationImmunoblotting (1:200-1:400)
      Immunoprecipitation (10 µl/mg protein lysate)
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~82 kDa HGF protein.
      BackgroundHepatocyte Growth Factor (HGF), also known as Scatter Factor (SF) and Hepatopoietin A, is a pleiotrophic growth factor which is produced by mesodermally derived cells such as endothelial cells, Kupffer cells/macrophages, and hepatic fat-storing cells. HGF/SF is a potent effector of growth, movement, differentiation and invasiveness of epithelial and cancer cells. It can induce epithelial-mesenchymal conversion of epithelial cells in culture, support epithelial branching duct formation in the developing lung and elicit a potent organotrophic function for regeneration of liver, kidney and lung through epithelial-stromal interactions. HGF/SF is also a potent angiogenic molecule whose activity such as cell migration, proliferation, protease production, invasion and capillary tube formation is mediated through direct actions on vascular endothelial cells. Recent evidence has shown that HGF/SF is overexpressed in invasive human cancer, relative to non-invasive and benign conditions. In invasive breast cancers, the expression of HGF/SF is strongly correlated with von Willebrand Factor, a marker of endothelial cells. The invasive and metastatic signals given by HGF/SF are transduced through the c-met proto-oncogene product, a transmembrane tyrosine kinase that functions as the HGF/SF receptor.
      HostMouse
      Immunogen speciesHuman
      Immunogenrecombinant, human HGF protein
      Clone4C12.1
      IsotypeIgG2b
      Specieshuman
      Positive controlEndothelial cells, Kupffer cells, or macrophages
      FormLiquid
      FormulationIn 10 mM PBS, 0.2% BSA, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage if desired. Avoid freeze/thaw.
      Toxicity Standard Handling
      ReferencesToi, M., et al. 1998. Clin. Cancer Res. 4, 659.
      Bardelli, A. and Comoglio, P.M. 1997. Ciba Found. Symp. 212, 133.
      Birchmeier, C., et al. 1997. Ciba Found. Symp. 212, 16.
      Jiang, W.G. and Hiscox, S. 1997. Histol. Histopathol. 12, 537.
      Matsumoto, K. and Nakamura, T. 1997. Ciba Found. Symp. 212, 198.
      Rosen, E.M., et al. 1997. Ciba Found. Symp. 212, 215.
      Vande Woude, G.F., et al. 1997. Ciba Found Symp. 212, 119.