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AB4087 Anti-Protein Phosphatase 2 A/B δ Antibody

Detect Protein Phosphatase 2 A/B δ using this Anti-Protein Phosphatase 2 A/B δ Antibody validated for use in IF & WB.

Research Category: Signaling Research Sub-Category: Kinases & Phosphatases, Kinases & Phosphatases Gene Symbol: PPP2R5D, MGC8949, MGC2134, OTTHUMP00000039821, B56D UniProt Number: Q14738
AB4087
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, RIF, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB4087
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Protein Phosphatase 2 A/B δ Antibody
      Background InformationPP2A is a heterotrimeric phosphatase, composed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma. The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. Bdelta is a novel isoform of the B class of PP2A regulatory subunits. It is widely expressed in rat tissues and appears to be involved in targeting PP2A to the cytosolic compartment.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Provided as 0.2μm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.
      Applications
      ApplicationDetect Protein Phosphatase 2 A/B δ using this Anti-Protein Phosphatase 2 A/B δ Antibody validated for use in IF & WB.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      Application NotesWestern blot

      Immunofluorescence

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide conjugated to KLH derived from the N-terminus of PP2A/B delta.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes the Bdelta regulatory subunit isotype of protein phosphatase 2A (PP2A).
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
      Gene Symbol
      • PPP2R5D
      • MGC8949
      • MGC2134
      • OTTHUMP00000039821
      • B56D
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14738 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
      SIZE: 602 amino acids; 69992 Da
      SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
      TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q14738 ## Belongs to the phosphatase 2A regulatory subunit B56 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      AB4087 04053252476129

      Documentation

      Verwandte Produkte & Anwendungen

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies