217699 Sigma-AldrichCdk1 Inhibitor IV, RO-3306 - Calbiochem
RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
More>> RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). Less<<Cdk1 Inhibitor IV, RO-3306 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| Empirical Formula |
|---|
| C₁₈H₁₃N₃OS₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 217699-5MG |
|
Glasflasche | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721). |
| Catalogue Number | 217699 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |
| Product Information | |
|---|---|
| ATP Competitive | Y |
| Form | Brown solid |
| Hill Formula | C₁₈H₁₃N₃OS₂ |
| Chemical formula | C₁₈H₁₃N₃OS₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Segment | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | Cdk1 |
| Primary Target K<sub>i</sub> | 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade ITEM Number | |
|---|---|
| Bestellnummer | GTIN |
| 217699-5MG | 04055977202342 |
Documentation
Cdk1 Inhibitor IV, RO-3306 - Calbiochem SDB
| Titel |
|---|
Cdk1 Inhibitor IV, RO-3306 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 217699 |
Literatur
| Übersicht |
|---|
| Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |