Millipore Sigma Vibrant Logo

487957 NOC-18 - CAS 146724-94-9 - Calbiochem

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

NOC-18 - CAS 146724-94-9 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

View Products on Sigmaaldrich.com
487957
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
146724-94-9C₄H₁₃N₅O₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
487957-10MG
Verfügbarkeit wird abgerufen...
—
Erfüllung und Lieferung verzögert Erfüllung und Lieferung verzögert
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Kst.-Ampulle 10 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro. Half-life (t½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
      Catalogue Number487957
      Brand Family Calbiochem®
      SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
      References
      ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
      Product Information
      CAS number146724-94-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₁₃N₅O₂
      Chemical formulaC₄H₁₃N₅O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetA nitric oxide (NO) donor
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      487957-10MG 04055977200430

      Documentation

      NOC-18 - CAS 146724-94-9 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      NOC-18 - CAS 146724-94-9 - Calbiochem Analysenzertifikate

      TitelChargennummer
      487957

      Literatur

      Übersicht
      Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2019 JSW
      SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
      DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro.
      FormWhite solid
      CAS number146724-94-9
      Chemical formulaC₄H₁₃N₅O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Solubility0.1N NaOH (10 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
      Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
      Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
      Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

      Verwandte Produkte & Anwendungen

      Related Products

      Bestellnummer Beschreibung  
      487950 NOC-5 - CAS 146724-82-5 - Calbiochem Preis & Verfügbarkeit
      487955 NOC-12 - CAS 146724-89-2 - Calbiochem Preis & Verfügbarkeit

      Kategorien

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Nitric Oxide Donors/Precursors