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MABF3097-100UG Anti-KIR2DL1/CD158a/h Antibody, clone 11PB6

Anti-KIR2DL1/CD158a/h, clone 11PB6, Cat. No. MABF3097, is a mouse monoclonal antibody that detects KIR2DL1/CD158a/h and is tested for use in Flow Cytometry.

MABF3097-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF3097-100UG
      DescriptionAnti-KIR2DL1/CD158a/h Antibody, clone 11PB6
      Alternate Names
      • Killer cell immunoglobulin-like receptor 2DL1
      • CD158 antigen-like family member A
      • Natural killer-associated transcript 1
      • NKAT-1
      • p58 natural killer cell receptor clones CL-42/47.11
      • p58 NK receptor CL-42/47.11
      • p58.1 MHC class-I-specific NK receptor
      • CD158a
      Background InformationKiller cell immunoglobulin-like receptor 2DL1 (UniProt: P43626; also known as CD158 antigen-like family member A, Natural killer-associated transcript 1, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, p58 NK receptor CL-42/47.11, p58.1 MHC class-I-specific NK receptor, CD158a) is encoded by the KIR2DL1 (also known as CD158A, NKAT1) gene (Gene ID: 3802) in human. Killer-cell immunoglobulin-like receptors (KIRs) are cell surface glycoproteins predominantly expressed on Natural Killer (NK) Cells. They are shown to interact with MHC class I molecules to control cell lysis. KIR2DL1 is a single-pass type I membrane glycoprotein that is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off to produce the mature protein that contains an extracellular domain (aa 22-245), a transmembrane domain (aa 246-264), and a cytoplasmic domain (aa 265-348). It also contains tow Ig-like C2-type domains (aa 42-107 and 142-205). It is expressed on NK cells and serves as a receptor for some HLA-C alleles such as w4 and w6. It is shown to Inhibit the activity of NK cells and prevent cell lysis. Two isoforms of KIR2DL1 have been described that are produced by alternative splicing. (Ref.: Meazza, R., et al. (2022). HLA. 100(2); 119-132; Falco, M., et al. (2010). J. Immunol. 185(1); 433-441).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality SegmentMQ200
      Applications
      ApplicationAnti-KIR2DL1/CD158a/h, clone 11PB6, Cat. No. MABF3097, is a mouse monoclonal antibody that detects KIR2DL1/CD158a/h and is tested for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesTested Applications

      Flow Cytometry Analysis: A representative lot detected KIR2DL1/CD158a/h in Flow Cytometry applications (Falco, M., et al. (2010). J Immunol. 185(1): 433-41).

      Flow Cytometry Analysis: A representative lot detected KIR2DL1/CD158a/h in Human pweripheral blood mononuclear cells (PBMC). (Courtesy of Dr. Raffaella Meazza, IRCCS Ospedale Policlinico San Martino, Genova, Italy).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenActivated human natural killer (NK) cells.
      EpitopeExtracellular domain
      Clone11PB6
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone 11PB6 is a mouse monoclonal antibody that detects Killer cell immunoglobulin-like receptor 2DL1 (CD158a/h). It targets an epitope within the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KIR2DL1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight38.58 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in Human peripheral blood mononuclear cells (PBMC).

      Flow Cytometry Analysis: 1 µg of this antibody detected KIR2DL1/CD158a/h in one million Human peripheral blood mononuclear cells (PBMC).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      MABF3097-100UG 04065271175006

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