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ABT40 Anti-MFAP-5 (MAGP2) Antibody

This Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2).

Anti-MFAP-5 (MAGP2) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Glycobiology, Adhesion (CAMs) Gene Symbol: MFAP5, MAGP2 UniProt Number: Q13361
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ABT40
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT40
      DescriptionAnti-MFAP-5 (MAGP2) Antibody
      Alternate Names
      • Microfibrillar-associated protein 5
      • MFAP-5
      • MP25
      • Microfibril-associated glycoprotein 2
      • MAGP-2
      Background InformationMicrofibril-associated protein 2 (MAGP-2), also known as microfibrillar associated protein 5 (MFAP-5), is a multifunctional secreted protein that acts as a promoter of tumor cell survival and angiogenesis. Through alphaVbeta3 integrin-mediated signaling, it is suggested that MAGP2 may provide a potential mechanistic link between MAGP2 and angiogenesis, as well as patient survival. Based on a high level of homology between MAGP (MFAP-2) and MAGP-2, both proteins are shown to bind to and activate Notch-1, as well as mediate the subsequent release of the Notch-1 extracellular domain.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human skeletal muscle tissue lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality SegmentMQ100
      Applications
      ApplicationThis Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human MFAP-5 (MAGP-2).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.
      Gene Symbol
      • MFAP5
      • MAGP2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Component of the elastin-associated microfibrils.

      SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.
      Molecular Weight~19 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human skeletal muscle tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected MFAP-5 (MAGP-2) in skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      ABT40 04053252633300