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ABF114 Anti-MSR1/CD204 Antibody

Anti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC.

Anti-MSR1/CD204 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: MSR1, SCARA1 UniProt Number: P21757
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ABF114
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF114
      DescriptionAnti-MSR1/CD204 Antibody
      Alternate Names
      • Macrophage scavenger receptor types I and II
      • Macrophage acetylated LDL receptor I and II
      • Scavenger receptor class A member 1
      • CD204
      Background InformationMacrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality SegmentMQ100
      Applications
      ApplicationAnti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected MSR1/CD204 in 1X10E6 K562 myelogenous leukemia cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human MSR1/CD204.
      EpitopeExtracellular domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MSR1
      • SCARA1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~42 & ~49 kDa observed. This antibody is predicted to cross-react with all isoforms of MSR1/CD204 (Isoform 1 - ~49 kDa, Isoform 2 - ~40 kDa, and Isoform 3 - ~42 kDa).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in THP-1 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected MSR1/CD204 in 10 µg of THP-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      ABF114 04055977115970