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AB5390-50UL Anti-Sodium Channel Nav1.7 Antibody, Pain

Detect Sodium Channel Nav1.7 using this Anti-Sodium Channel Nav1.7 Antibody, Pain validated for use in IH & WB.

Anti-Sodium Channel Nav1.7 Antibody, Pain MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN9A, NE-NA, NENA, ETHA, Nav1.7, hNE-Na, PN1 UniProt Number: Q15858
AB5390-50UL
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5390-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Sodium Channel Nav1.7 Antibody, Pain
      Alternate Names
      • NENA
      • NE
      • SCN9A
      • PN1
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality SegmentMQ100
      Applications
      ApplicationDetect Sodium Channel Nav1.7 using this Anti-Sodium Channel Nav1.7 Antibody, Pain validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat brain membranes.

      Immunohistochemistry on rat dorsal root ganglion (DRG) frozen sections.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified peptide from rat Nav1.7 (amino acids 446-460) (Accession AAB50403).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Nav1.7 protein (PN1, NENA, NE, Type IX Voltage Gated Sodium Channel, Scn9a). The epitope is specific for Nav1.7 and is not present in any other known protein.

      SPECIES REACTIVITIES: The immunogen sequence is highly conserved in rabbit and human (14/15 and 13/15 respectively). Other species have not been tested.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SCN9A
      • NE-NA
      • NENA
      • ETHA
      • Nav1.7
      • hNE-Na
      • PN1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15858 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).
      SIZE: 1988 amino acids; 226342 Da
      SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=In neurite terminals (By similarity).
      TISSUE SPECIFICITY: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system while isoform 2 is expressed preferentially in the dorsal root ganglion.
      DOMAIN: SwissProt: Q15858 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
      PTM: Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4 (By similarity).
      DISEASE: SwissProt: Q15858 # Defects in SCN9A are the cause of primary erythermalgia [MIM:133020]. It is an autosomal dominant disease characterized by recurrent episodes of severe pain associated with redness and warmth in the feet or hands. & Defects in SCN9A are the cause of autosomal recessive congenital indifference to pain [MIM:243000]; also known as channelopathy-associated insensitivity to pain. Affected individuals have a congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating. & Defects in SCN9A are a cause of paroxysmal extreme pain disorder (PEPD) [MIM:167400]; previously known as familial rectal pain (FRP). PEPD is an autosomal dominant paroxysmal disorder of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as skin flushing.
      SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB5390-50UL 04053252332647

      Documentation

      Anti-Sodium Channel Nav1.7 Antibody, Pain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Sodium Channel Nav1.7 Antibody, Pain Certificates of Analysis

      TitleLot Number
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2121723 2121723
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2139983 2139983
      ANTI-SODIUM CHANNEL Nav1.7, PAIN - 3422850 3422850
      ANTI-SODIUM CHANNEL Nav1.7, PAIN -2576332 2576332
      ANTI-SODIUM CHANNEL Nav1.7, PAIN -2739413 2739413
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY 3062408
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 1983946 1983946
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 1994889 1994889
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2048771 2048771
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2344629 2344629

      Data Sheet

      Title
      ANTI-SODIUM CHANNEL Nav1.7, PAIN AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Alternative Packsize

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies