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1.00577

Water

Name: Water
Brand: MM

suitable for GC-HS, SupraSolv^®, according to USP and Ph. Eur.

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About This Item

Linear Formula:

H₂O

CAS Number:

7732-18-5

Molecular Weight:

18.02

UNSPSC Code:

41104213

NACRES:

NA.03

MDL number:

MFCD00011332

Beilstein/REAXYS Number:

2050024

Technique(s):

GC-HS: suitable

Bp:

100 °C (lit.)

Vapor pressure:

23 hPa ( 20 °C)

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Properties

Product Name

Water, for headspace gas chromatography SupraSolv^®

Quality Segment

100

agency

according to Ph. Eur., according to USP

vapor pressure

23 hPa ( 20 °C)

product line

SupraSolv^®

form

liquid

technique(s)

GC-HS: suitable

impurities

≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH

evapn. residue

≤5 mg/L

refractive index

n20/D 1.34 (lit.)

pH

7 (20 °C)

bp

100 °C (lit.)

mp

0 °C (lit.)

density

1.000 g/mL at 3.98 °C (lit.)

storage temp.

2-30°C

SMILES string

InChI

1S/H2O/h1H2

InChI key

XLYOFNOQVPJJNP-UHFFFAOYSA-N

Description

General description

SupraSolv^® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv^® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.

Application

SupraSolv^® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.

Analysis Note

SupraSolv^® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:• Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g• Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g• Class 3 solvents (low toxic potential): ≤ 50 µg/gThese specifications are verified lot-by-lot via GC/HS analysis, providing robust certification of compliance and analytical traceability.

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c