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MABS528 Anti-HGPRT Antibody, clone 13H11.1

This Anti-HGPRT, clone 13H11.1 is validated for use in Western Blotting for the detection of HGPRT.

Anti-HGPRT Antibody, clone 13H11.1 : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: HPRT1, HPRT UniProt Number: P00492
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MABS528
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS528
      DescriptionAnti-HGPRT Antibody, clone 13H11.1
      Alternate Names
      • Hypoxanthine-guanine phosphoribosyltransferase
      • HGPRT
      • HGPRTase
      Background InformationHypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8; UniProt P00492; also known as HGPRT, HGPRTase) is encoded by the HPRT1 (also known as HGPRT, HPRT) gene (Gene ID 3251) in human. HPRT is a purine salvage enzyme that catalyzes the condensation of 5-phosphoribosyl 1-pyrophosphate (PRPP) and hypoxanthine or guanine to form inosine 5-monophosphate (IMP) and guanosine 5-monophosphate (GMP), respectively. PRPP is an essential compound for the de novo pathway of purine synthesis as well as the synthesis of pyrimidine compounds. PRPP concentrations in erythrocyte are markedly increased in individuals with HPRT deficiency. Complete HPRT deficiency leads to Lesch–Nyhan disease (LND) characterized by uric acid overproduction, motor dysfunction, cognitive disability, and self-injurious behavior. Partial deficiency of HPRT activity causes Lesch–Nyhan variant (LNV) characterized by hyperuricemia and variable degree of neurological manifestations, depending on the residual enzyme activity.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality SegmentMQ100
      Applications
      ApplicationThis Anti-HGPRT, clone 13H11.1 is validated for use in Western Blotting for the detection of HGPRT.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged human HGPRT recombinant fragment lacking N- and C-terminal regions.
      EpitopeInternal
      Clone13H11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HPRT1
      • HPRT
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~25 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected HGPRT in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      MABS528 04055977274974

      Documentation

      Anti-HGPRT Antibody, clone 13H11.1 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-HGPRT Antibody, clone 13H11.1 Analysenzertifikate

      TitelChargennummer
      Anti-HGPRT, clone 13H11.1 -Q2592796 Q2592796

      Broschüre

      Titel
      New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody

      Technische Informationen

      Titel
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.

      Posters

      Titel
      Post-Translational Modifications