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444294 MMP-2 Inhibitor IV - Calbiochem

The MMP-2 Inhibitor IV controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MMP-2 Inhibitor IV - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Bone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₃H₁₄ClNO₈P₂S
      Description
      OverviewA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
      Catalogue Number444294
      Brand Family Calbiochem®
      SynonymsBone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
      References
      ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₃H₁₄ClNO₈P₂S
      Chemical formulaC₁₃H₁₄ClNO₈P₂S
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      444294 0

      Documentation

      MMP-2 Inhibitor IV - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      MMP-2 Inhibitor IV - Calbiochem Analysenzertifikate

      TitelChargennummer
      444294

      Literatur

      Übersicht
      Rubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-July-2012 JSW
      SynonymsBone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
      DescriptionA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₄ClNO₈P₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.