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370679 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI

Primary Target: PKG1α & 1β
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370679
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
172806-20-1C₁₈H₁₄BrN₅O₆PS · Na

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370679-1UMOL
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      		 Plastic ampoule 1 umol
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      Description
      OverviewA metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.
      Catalogue Number370679
      Brand Family Calbiochem®
      SynonymsRp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
      References
      ReferencesWei, J.Y., et al. 1996. Biochemistry 35, 16815.
      Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
      Product Information
      CAS number172806-20-1
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₈H₁₄BrN₅O₆PS · Na
      Chemical formulaC₁₈H₁₄BrN₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetPKG1α & 1β
      Primary Target K<sub>i</sub>30 nM against PKG1α & 1β
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      370679-1UMOL 04055977191714

      Documentation

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      370679

      References

      Reference overview
      Wei, J.Y., et al. 1996. Biochemistry 35, 16815.
      Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-October-2007 JSW
      SynonymsRp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
      DescriptionA metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
      FormLyophilized
      CAS number172806-20-1
      Chemical formulaC₁₈H₁₄BrN₅O₆PS · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWei, J.Y., et al. 1996. Biochemistry 35, 16815.
      Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.