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AB3865 Anti-CaMKII Antibody, phospho-specific (Thr305)

Detect CaMKII using this Anti-CaMKII Antibody, phospho-specific (Thr305) validated for use in WB.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: CAMK2A, KIAA0968, CAMKA, EC 2.7.11.17 UniProt Number: Q9UQM7
AB3865
100 µL  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Dr, H, M, RWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB3865
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CaMKII Antibody, phospho-specific (Thr305)
      References
      Product Information
      FormatSerum
      PresentationNeat serum.
      Applications
      ApplicationDetect CaMKII using this Anti-CaMKII Antibody, phospho-specific (Thr305) validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1000

      Dot blots: 1:1000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Thr305 of CaMKII. Sequence is identical in human, mouse, rat, bovine, chicken, Drosophila, and Limulus and in alpha, beta, and delta isoforms.
      Epitopephospho-specific (Thr305)
      HostRabbit
      SpecificityRecognizes the alpha, beta and gamma isoforms of CaMKII (Ca2+/calmodulin-dependent protein kinase II) when phosphorylated at Thr305. CaMKII is a prominent serine/threonine kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
      Species Reactivity
      • Drosophila
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
      Gene Symbol
      • CAMK2A
      • KIAA0968
      • CAMKA
      • EC 2.7.11.17
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
      SIZE: 478 amino acids; 54030 Da
      SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
      SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
      SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20ºC for up to one year from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      AB3865 04053252738708

      Documentation

      Anti-CaMKII Antibody, phospho-specific (Thr305) FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-CaMKII Antibody, phospho-specific (Thr305) Certificats d'analyse

      TitreNuméro de lot
      RABBIT ANTI-PHOSPHO-CaMKII (Thr305) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2067748 2067748
      RABBIT ANTI-PHOSPHO-CaMKII (Thr305) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2216813 2216813

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
      Elgersma, Ype, et al.
      Neuron, 36: 493-505 (2002)  2002

      Afficher le résumé       		12408851 12408851

      Fiche technique

      Titre
      RABBIT ANTI-PHOSPHO-CaMKII (Thr305) AFFINITY PURIFIED POLYCLONAL ANTIBODY

      Produits & Applications associés

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies