Millipore Sigma Vibrant Logo

AB5820-200UL Anti-Syntaxin 1 Antibody

Detect Syntaxin 1 using this Anti-Syntaxin 1 Antibody validated for use in WB, IH.

Anti-Syntaxin 1 Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: STX1A, HPC-1, STX1, Syntaxin-1A, p35-1 UniProt Number: Q16623
AB5820-200UL
200 µL  
Ricerca del prezzo in corso...
Non è stato possibile trovare il prezzo
La quantità minima deve essere un multiplo di
Maximum Quantity is
Al termine dell'ordine Maggiori informazioni
Lei ha salvato ()
 
—
Richiedi il prezzo
—
Adempimento e consegna in ritardo Adempimento e consegna in ritardo
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      Offerte speciali

       

      Contatti il Servizio Clienti

      Panoramica

      Replacement Information

      Offerte speciali

      100% Performance Guaranteed

      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5820-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Syntaxin 1 Antibody
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 50 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of PBS. For positive control, in Western blot using 50 ng of protein per Minigel lane. For negative control, preincubate 5-10 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality SegmentMQ100
      Applications
      ApplicationDetect Syntaxin 1 using this Anti-Syntaxin 1 Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blot: 1:1000 using ECL on rat brain membranes.

      Immunohistochemistry on rat brain sections: AB5820 is directed against an intracellular epitope. Thus, a procedure including permeabilization of cells with 0.2% Triton X 100 is recommended. It is recommended that you start with a working concentration of 30 μg/mL (1:33).

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGST fusion protein corresponding to a cytoplasmic part of rat Syntaxin 1A (Accession number P32851) (Bennet et al. 1992; Inoue & Akagawa 1992).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Syntaxin 1A and Syntaxin 1B. The epitope does not share homology with any other known proteins.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySynaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]
      Gene Symbol
      • STX1A
      • HPC-1
      • STX1
      • Syntaxin-1A
      • p35-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16623 # Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.
      SIZE: 288 amino acids; 33023 Da
      SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25 (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein. & Isoform 2: Secreted (Probable).
      TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
      DISEASE: SwissProt: Q16623 # Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
      SIMILARITY: SwissProt: Q16623 ## Belongs to the syntaxin family. & Contains 1 t-SNARE coiled-coil homology domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Numero di catalogo GTIN
      AB5820-200UL 04053252402524

      Documentation

      Anti-Syntaxin 1 Antibody MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Anti-Syntaxin 1 Antibody Certificati d'Analisi

      TitoloNumero di lotto
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2115996 2115996
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2143478 2143478
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2378686 2378686
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2452697 2452697
      RABBIT ANTI-SYNTAXIN 1 - 3258313 3258313
      RABBIT ANTI-SYNTAXIN 1 - 3496501 3496501
      RABBIT ANTI-SYNTAXIN 1 -2550863 2550863
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY 2985047
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2067240 2067240
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY - 2088975 2088975

      Riferimenti bibliografici

      Panoramica dei riferimenti bibliograficiCodice d'identificazione nel Pub Med
      Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones.
      Bennett, M K, et al.
      Science, 257: 255-9 (1992)  1992

      		1321498 1321498
      Neuron-specific antigen HPC-1 from bovine brain reveals strong homology to epimorphin, an essential factor involved in epithelial morphogenesis: identification of a novel protein family.
      Inoue, A and Akagawa, K
      Biochem. Biophys. Res. Commun., 187: 1144-50 (1992)  1992

      Mostra il sommario       		1530610 1530610

      Scheda tecnica

      Titolo
      RABBIT ANTI-SYNTAXIN 1 POLYCLONAL ANTIBODY

      Prodotti e applicazioni correlate

      Related Products

      Numero di catalogo Descrizione  
      AB5820-50UL Anti-Syntaxin 1 Antibody Prezzi e disponibilità
      MAB336 Anti-Syntaxin Antibody, clone SP8 Prezzi e disponibilità
      MAB336-C Anti-Syntaxin-1A Antibody, clone SP8 (Ascites Free) Prezzi e disponibilità

      Alternative Packsize

      Numero di catalogo Descrizione  
      AB5820-50UL Anti-Syntaxin 1 Antibody Prezzi e disponibilità

      Linee di prodotti

      Nervous System Markers

      The nervous system coordinates the voluntary and involuntary actions of the individual and transmits signals between different parts of the body.
      Per saperne di più >>

      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies