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SCT242 BioTracker CDg16 Activated Macrophage Probe

Small molecule green fluorescent probe specific for activated macrophages for imaging inflammation.

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SCT242
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT242
      DescriptionBioTracker CDg16 Activated Macrophage Probe
      OverviewThe BioTracker™ CDg16 Activated Macrophage Probe is a fluorescent probe used to detect M1 classically-activated macrophages that emits in the green spectrum for imaging and detection (Park, 2019).

      Macrophages play a critical role in the innate immune response. Classically-activated or M1 macrophages are typically classified as proinflammatory. Identifying macrophages activated to induce inflammatory responses is therefore important when assessing inflammation during research into the progression and treatment of related diseases such as atherosclerosis, hepatitis, and cancer. Unlike many macrophage probes which cannot appropriately distinguish between M1 activated and non-activated cells.

      Spectral Properties
      Fluorescence images obtained by λex = 488 nm and emission at 520 nm.

      Reference
      Park, Sung-Jin, et al. "Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target." Nature communications 10.1 (2019): 1-7.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Yellow solid.
      Quality SegmentMQ100
      Applications
      ApplicationSmall molecule green fluorescent probe specific for activated macrophages for imaging inflammation.
      Key Applications
      • Cell Based Assays
      • Flow Cytometry
      • Fluorescence
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight597.54
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by UPLC. Identification confirmed by H NMR, F NMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, dessicated and protected from light.
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Numero di catalogo GTIN
      SCT242 04065267532219