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438185 Lovastatin - CAS 75330-75-5 - Calbiochem

Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

Lovastatin - CAS 75330-75-5 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Mevinolin, MK-803, L-Type Calcium Channel Blocker IV

Primary Target: Activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
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      Replacement Information

      Tabella delle specifiche principali

      CAS #Empirical Formula
      75330-75-5C₂₄H₃₆O₅
      Description
      OverviewAn anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
      Catalogue Number438185
      Brand Family Calbiochem®
      SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
      References
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.
      Product Information
      CAS number75330-75-5
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₂₄H₃₆O₅
      Chemical formulaC₂₄H₃₆O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ200
      Applications
      Biological Information
      Primary TargetActivity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEK7907000
      Safety Information
      R PhraseR: 63

      Possible risk of harm to the unborn child.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Numero di catalogo GTIN
      438185 0

      Documentation

      Lovastatin - CAS 75330-75-5 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Lovastatin - CAS 75330-75-5 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      438185

      Riferimenti bibliografici

      Panoramica delle referenze
      Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
      DescriptionAn anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that blocks a series of biological events including: activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
      FormWhite to off-white powder
      Recommended reaction conditionsActivation Protocols: Liu, Li., et al. 1999. J. Biol. Chem. 274, 33334. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      CAS number75330-75-5
      RTECSEK7907000
      Chemical formulaC₂₄H₃₆O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 5586
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.