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482210 Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide

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482210
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CAS #Empirical Formula
1021926-22-6C₂₄H₃₂N₂O₄S

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482210-5MG
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      Description
      OverviewA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
      Catalogue Number482210
      Brand Family Calbiochem®
      SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
      References
      ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
      Su, B., et al. 2008. J. Comb. Chem. 10, 475.
      Product Information
      CAS number1021926-22-6
      FormOff-white solid
      Hill FormulaC₂₄H₃₂N₂O₄S
      Chemical formulaC₂₄H₃₂N₂O₄S
      Quality SegmentMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Numero di catalogo GTIN
      482210-5MG 04055977183504

      Documentation

      Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      482210

      Riferimenti bibliografici

      Panoramica delle referenze
      Chen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
      Su, B., et al. 2008. J. Comb. Chem. 10, 475.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
      DescriptionA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
      FormOff-white solid
      CAS number1021926-22-6
      Chemical formulaC₂₄H₃₂N₂O₄S
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
      Su, B., et al. 2008. J. Comb. Chem. 10, 475.