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524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: TPA, PMA, PKC Activator I

Primary Target: Protein Kinase C
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      Panoramica

      Replacement Information

      Tabella delle specifiche principali

      CAS #Empirical Formula
      16561-29-8C₃₆H₅₆O₈
      Description
      OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
      Catalogue Number524400
      Brand Family Calbiochem®
      SynonymsTPA, PMA, PKC Activator I
      References
      ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.
      Product Information
      CAS number16561-29-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₆H₅₆O₈
      Chemical formulaC₃₆H₅₆O₈
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
      Biological Information
      Primary TargetProtein Kinase C
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQH4377000
      Safety Information
      R PhraseR: 21-38

      Harmful in contact with skin.
      Irritating to skin.
      S PhraseS: 26-27-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Take off immediately all contaminated clothing.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Numero di catalogo GTIN
      524400 0

      Documentation

      Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      524400

      Riferimenti bibliografici

      Panoramica delle referenze
      Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.

      Brochure

      Titolo
      Caspases and other Apoptosis Related Tools Brochure

      Citazioni

      Titolo
    • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
    • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
    • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
    • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-October-2010 JSW
      SynonymsTPA, PMA, PKC Activator I
      DescriptionExtremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number16561-29-8
      RTECSQH4377000
      Chemical formulaC₃₆H₅₆O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
      Toxicity Harmful
      ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.
      Citation
    • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
    • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
    • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
    • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
      		•