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ABN444 Anti-Amyloid-like protein 1 Antibody

This Anti-Amyloid-like protein 1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Amyloid-like protein 1.

Anti-Amyloid-like protein 1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience, Neuroscience Research Sub-Category: Neurodegenerative Diseases, Synapse & Synaptic Biology Gene Symbol: APLP1 UniProt Number: P51693
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ABN444
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN444
DescriptionAnti-Amyloid-like protein 1 Antibody
Alternate Names
  • APLP-1
  • APLP
  • APLP1
  • Amyloid-like protein-1
Background InformationAmyloid-like protein 1 or APLP-1 is neuronal, membrane bound specific protein that likely has a role in post-synaptic function but most research has focused on its proteolytic fragments such as ALID1 which acts as a transcriptional activator through binding the co-activator APBB1. APLP-1 fragments also interact with various G-protein coupled receptor pathways and appear to have a role in synaptic maturation during cortical development. APLP-1 also appears to regulate neurite outgrowth through binding to components of the ECM such as heparin and collagen I. Finally a special fragment called C30 is a potent enhancer of neuronal apoptosis and is a caspase specific cleavage fragment that works internally inducing apoptosis. Thus APLP-1 has roles in apoptosis, cell adhesion, endocytosis, cell signaling and neurite extension as well as some post-synaptic function as it is found clustered at post-synaptic densities in normal cells.
References
Product Information
FormatAffinity Purified
PresentationPurified Rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality SegmentMQ100
Applications
ApplicationThis Anti-Amyloid-like protein 1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Amyloid-like protein 1.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Amyloid-like protein 1 in human cerebral cortex and thalamic tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of Human Amyloid-like protein 1.
EpitopeExtracellular domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Rat, Mouse based on 100% sequence homology. Immunogen is 94% identical to Bovine
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • APLP1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~72 kDa observed. A ~90kDa band may appear in some lysates due to glycosylation: Kim. TW., et al. (1995). Brain Res Mol Brain Res. 32(1):36-44.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Human Cortex tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Amyloid-like protein 1 in 10 µg of Human Cortex tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
ABN444 04055977052015