Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABN241 Anti-GluR1 Antibody

Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).

Anti-GluR1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: Gria1, Glur1 UniProt Number: P19490
View Products on Sigmaaldrich.com
ABN241
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN241
ReplacesPC246-100UG
DescriptionAnti-GluR1 Antibody
Alternate Names
  • Glutamate receptor 1
  • GluR-1
  • AMPA-selective glutamate receptor 1
  • GluR-A
  • GluR-K1
  • Glutamate receptor ionotropic
  • AMPA 1
  • GluA1
Background InformationGlutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.
References
Product Information
FormatAffinity Purified
Control
  • Rat brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality SegmentMQ100
Applications
ApplicationAnti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1.
EpitopeExtracellular domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the extracellular domain of GluR1.
Species Reactivity
  • Mouse
  • Rat
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Gria1
  • Glur1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~110 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
ABN241 04053252906718

Documentation

Anti-GluR1 Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-GluR1 Antibody Certificates of Analysis

TitleLot Number
Anti-GluR1 2476946
Anti-GluR1 - 2383596 2383596
Anti-GluR1 - 2457127 2457127
Anti-GluR1 - 2325146 2325146
Anti-GluR1 - 3253334 3253334
Anti-GluR1 - 3380404 3380404
Anti-GluR1 - 3449057 3449057
Anti-GluR1 - 3485866 3485866
Anti-GluR1 - 3755420 3755420
Anti-GluR1 - 3933215 3933215
Show more

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer