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16-217 Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse

Anti-TNF alpha Antibody, clone 3B8, biotin conjugate, mouse is an antibody against TNFα for use in ELISA.

Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: TNF, TNFSF2, Cachectin, cachectin, TNF-alpha, DIF, OTTHUMP00000037669, TNFA, TNF-a UniProt Number: P01375
16-217
200 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MELISAHtBiotinMonoclonal Antibody
Description
Catalogue Number16-217
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-TNFα Antibody, clone 3B8, biotin conjugate, mouse
References
Product Information
FormatBiotin
Applications
ApplicationAnti-TNF alpha Antibody, clone 3B8, biotin conjugate, mouse is an antibody against TNFα for use in ELISA.
Key Applications
  • ELISA
Biological Information
ImmunogenRecombinant mouse TNFα expressed in E. coli.
Cloneclone 3B8
HostHamster
SpecificityTNFα
IsotypeIgG
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Gene Symbol
  • TNF
  • TNFSF2
  • Cachectin
  • cachectin
  • TNF-alpha
  • DIF
  • OTTHUMP00000037669
  • TNFA
  • TNF-a
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
SIZE: 233 amino acids; 25644 Da
SUBUNIT: Homotrimer.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted.
PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.
SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by ELISA
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at 4°C from date of shipment
Packaging Information
Material Size200 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
16-217 04053252272431

Documentation

Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse Certificates of Analysis

TitleLot Number
Anti-TNFa, clone 3B8, biotin conjugate, mouse - 2204368 2204368
Anti-TNFalpha;, clone 3B8, biotin conjugate, mouse - 30315 30315
Anti-TNFα, clone 3B8, biotin conjugate, mouse -2530529 2530529

References

Reference overviewPub Med ID
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction.
Muppidi, Jagan R, et al.
Immunity, 21: 461-5 (2004)  2004

Show Abstract 		15485624 15485624

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies