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508509 NS309 - CAS 18711-16-5 - Calbiochem

A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO.

NS309 - CAS 18711-16-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ca2+ -activated K+ Channels Activator, NS309, NS-309, NS 309

Primary Target: Ca2+-activated K+ channels
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
18711-16-5C₈H₄Cl₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
5.08509.0001 Glass bottle 10 mg
Description
OverviewA potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508509
Brand Family Calbiochem®
SynonymsCa2+ -activated K+ Channels Activator, NS309, NS-309, NS 309
References
ReferencesLeurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.
Product Information
CAS number18711-16-5
FormYellow solid
Hill FormulaC₈H₄Cl₂N₂O₂
Chemical formulaC₈H₄Cl₂N₂O₂
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
Biological Information
Primary TargetCa2+-activated K+ channels
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
5.08509.0001 04055977262025

Documentation

NS309 - CAS 18711-16-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-January-2014 JSW
SynonymsCa2+ -activated K+ Channels Activator, NS309, NS-309, NS 309
DescriptionA potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.
FormYellow solid
CAS number18711-16-5
Chemical formulaC₈H₄Cl₂N₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLeurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.