Save time using our sizing tool for buffer filtration

Buffer solutions are a key requirement in various process steps of pharmaceutical and biotechnology therapeutics including: cell culture media, chromatography, ultrafiltration, diafiltration, and final formulation. Sterile filtration of buffer solutions using 0.2 µm filters is commonly performed to control process bioburden and remove physical contaminants.

Today, the Vmax™ filter sizing method is often used to estimate filter size requirements for normal flow membrane filters in a variety of applications. The Vmax™ filter sizing model assumes filter pores plug gradually over time and requires experimental filtration work to be carried out at constant pressure using the test solution and a membrane filter.

At Merck, we've developed a sizing tool to help you approximate filter size requirements for simple filtration applications, such as buffer filtration. Based on generic values of membrane permeability, this simplified sizing technique does not require experimental work and still provides similar results to the classical Vmax™ testing method. As a result, you can save time and focus on more critical operations.

To use our generic buffer sizing tool and discover how we build it, view our poster by clicking the button below.

For more information, please click here.

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