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203800 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 8-Bromo-cAMP, Na

Primary Target: PKA
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
76939-46-3C₁₀H₁₀BrN₅O₆P · Na

Products

产品目录编号包装 数量 / 包装
203800-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewCell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
Catalogue Number203800
Brand Family Calbiochem®
Synonyms8-Bromo-cAMP, Na
References
ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
Product Information
CAS number76939-46-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₀BrN₅O₆P · Na
Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
HS Code2934 99 99
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
ApplicationAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.
Biological Information
Primary TargetPKA
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
产品目录编号 GTIN
203800-10MGCN 04055977203998

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem 分析证书

标题批号
203800

参考

参考信息概述
Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.

引用

标题
  • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision21-May-2008 RFH
    Synonyms8-Bromo-cAMP, Na
    DescriptionCell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.
    FormWhite solid
    CAS number76939-46-3
    Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityH₂O
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
    Toxicity Standard Handling
    ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
    de Rooij, J., et al. 1998. Nature 396, 474.
    Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
    Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
    Citation
  • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
    		•