Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABC843 Anti-GITRL Antibody

Detect GITRL using this Anti-GITRL Antibody validated for use in western blotting & ICC.

Anti-GITRL Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TNFSF18, AITRL, GITRL, TL6 UniProt Number: Q9UNG2
View Products on Sigmaaldrich.com
ABC843
100 µg  
Purchase on Sigma-Aldrich

特卖

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC843
DescriptionAnti-GITRL Antibody
Alternate Names
  • Tumor necrosis factor ligand superfamily member 18
  • Activation-inducible TNF-related ligand
  • AITRL
  • Glucocorticoid-induced TNF-related ligand
  • hGITRL
Background InformationTumor necrosis factor ligand superfamily member 18, also known as Activation-inducible TNF-related ligand (AITRL) or Glucocorticoid-induced TNF-related ligand (hGITRL) and encoded by the gene name TNFSF18 or AITRL or GITRL or TL6, regulates numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality SegmentMQ100
Applications
ApplicationDetect GITRL using this Anti-GITRL Antibody validated for use in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 10 μg/mL from a representative lot detected GITRL in THP-1 cells.
Biological Information
ImmunogenKLH-conjugated recombinant human GITRL ligand.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • TNFSF18
  • AITRL
  • GITRL
  • TL6
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~26 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in recombinant GITRL protein.

Western Blotting Analysis: 1 μg/mL of this antibody was detected in recombinant GITRL protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
产品目录编号 GTIN
ABC843 04053252943942