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MABS528 Sigma-AldrichAnti-HGPRT Antibody, clone 13H11.1

This Anti-HGPRT, clone 13H11.1 is validated for use in Western Blotting for the detection of HGPRT.

Anti-HGPRT Antibody, clone 13H11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
小册子
技术信息
Posters

Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: HPRT1, HPRT UniProt Number: P00492

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABS528
Description	Anti-HGPRT Antibody, clone 13H11.1
Alternate Names	Hypoxanthine-guanine phosphoribosyltransferase HGPRT HGPRTase
Background Information	Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8; UniProt P00492; also known as HGPRT, HGPRTase) is encoded by the HPRT1 (also known as HGPRT, HPRT) gene (Gene ID 3251) in human. HPRT is a purine salvage enzyme that catalyzes the condensation of 5-phosphoribosyl 1-pyrophosphate (PRPP) and hypoxanthine or guanine to form inosine 5-monophosphate (IMP) and guanosine 5-monophosphate (GMP), respectively. PRPP is an essential compound for the de novo pathway of purine synthesis as well as the synthesis of pyrimidine compounds. PRPP concentrations in erythrocyte are markedly increased in individuals with HPRT deficiency. Complete HPRT deficiency leads to Lesch–Nyhan disease (LND) characterized by uric acid overproduction, motor dysfunction, cognitive disability, and self-injurious behavior. Partial deficiency of HPRT activity causes Lesch–Nyhan variant (LNV) characterized by hyperuricemia and variable degree of neurological manifestations, depending on the residual enzyme activity.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Segment	MQ100

Applications
Application	This Anti-HGPRT, clone 13H11.1 is validated for use in Western Blotting for the detection of HGPRT.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged human HGPRT recombinant fragment lacking N- and C-terminal regions.
Epitope	Internal
Clone	13H11.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2bκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000185
Gene Symbol	HPRT1 HPRT
Purification Method	Protein G Purified
UniProt Number	P00492
Molecular Weight	~25 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected HGPRT in 10 µg of HeLa cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade ITEM Number
产品目录编号	GTIN
MABS528	04055977274974

Documentation

Anti-HGPRT Antibody, clone 13H11.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-HGPRT Antibody, clone 13H11.1 分析证书

标题	批号
Anti-HGPRT, clone 13H11.1 -Q2592796	Q2592796

小册子

标题
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技术信息

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海报

标题
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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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