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AB15644 Anti-HuD Antibody

This Anti-HuD Antibody is validated for use in WB for the detection of HuD.

Anti-HuD Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience, Neuronal & Glial Markers Gene Symbol: HUD, PNEM , ELAVL4 , OTTHUMP00000009612 UniProt Number: P26378
AB15644
100 µg  
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特卖

概述

Replacement Information
Replacement InformationAB05644 is a recommended replacement for AB5971

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, R, MWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB15644
ReplacesAB5971
DescriptionAnti-HuD Antibody
Alternate Names
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
  • ELAV-like 4
  • Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4
  • Hu-antigen D
  • Paraneoplastic encephalomyelitis antigen HuD
Background InformationELAV-like protein 4 (ELAVL4) also know as Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and consists of two N-terminal RNA recognition motifs (RRM1 and -2), a hinge region, and a C-terminal RRM (RRM3). Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. HuD is localized and expressed in brain tissue immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. HuD has been linked with the disease, paraneoplastic encephalomyelitis sensory neuropathy, which is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities.
References
Product Information
FormatPurified
Control
  • Human Brain lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM sodium chloride with 0.05% sodium azide.
Applications
ApplicationThis Anti-HuD Antibody is validated for use in WB for the detection of HuD.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide a.a. 26-42.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityAntibody recognizes HuD.
Species Reactivity
  • Human
  • Rat
  • Mouse
Species Reactivity NoteTested on human, mouse, and rat. Sequence Homology 100% with rat, mouse, human, primate, dog, cow
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • HUD
  • PNEM
  • ELAVL4
  • OTTHUMP00000009612
Purification MethodAntigen Affinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P26378 # May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity).
SIZE: 380 amino acids; 41760 Da
SUBUNIT: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity).
TISSUE SPECIFICITY: Brain.
PTM: Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
DISEASE: SwissProt: P26378 # Paraneoplastic encephalomyelitis sensory neuropathy is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. It may result from an immune response primarily directed against a small cell lung tumor antigen which is misdirected against similar antigens expressed in brain.
SIMILARITY: SwissProt: P26378 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
Molecular WeightApprox. 42 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by western blot on human brain lysate
Western Blot:
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
产品目录编号 GTIN
AB15644 04053252672460