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AB15134 Anti-Neurotensin Receptor 2 Antibody

Detect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.

Anti-Neurotensin Receptor 2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience, Metabolism Research Sub-Category: Neurotransmitters & Receptors, Hormones & Receptors Gene Symbol: NTSR2, NTR2, NT-R-2 UniProt Number: O95665
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AB15134
100 µg  
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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB15134
ReplacesAB9521
DescriptionAnti-Neurotensin Receptor 2 Antibody
Alternate Names
  • Levocabastine-sensitive neurotensin receptor
  • NTR2 receptor
  • neurotensin receptor 2
  • neurotensin receptor, type 2
Background InformationNeurotensin Receptor 2 (NTR2) is a member of the G-protein coupled receptor family. Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents (Kinkead and Nemeroff, 2004). In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin (Castagliuolo et al., 1999). The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR2 recognizes a histamine H1 receptor antagonist that had been shown to compete with neurotensin for low-affinity binding sites in the brain.
References
Product Information
FormatAffinity Purified
Control
  • Human cortex lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Quality SegmentMQ100
Applications
ApplicationDetect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of mouse brain lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of rat brain lysate.
Biological Information
ImmunogenKLH-conjugated linear peptide from the extracellular domain of human Neurotensin Receptor 2.
EpitopeExtracellular Domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes Neurotensin Receptor 2.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteProven to react with human, mouse, and rat.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq]
Gene Symbol
  • NTSR2
  • NTR2
  • NT-R-2
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.

SIZE: 410 amino acids; 45413 Da

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Molecular Weight45.413 kDa is the calculated molecular weight. In Western Blot, immunoreactive bands which might reflect multimeric species of Neurotensin Receptor 2, are detected at approximately 60-65 kDa, 75 kDa, and 80-85 kDa. Sarret, P., et al. (2003). J Comp Neurol. 461(4):520-538.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human cortex lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of human cortex lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
产品目录编号 GTIN
AB15134 04053252333873

Documentation

Anti-Neurotensin Receptor 2 Antibody MSDS

职位

物料安全数据表 (MSDS) 

Anti-Neurotensin Receptor 2 Antibody 分析证书

标题批号
Anti-Neurotensin Receptor 2 3072301
Anti-Neurotensin Receptor 2 - 2565834 2565834
Anti-Neurotensin Receptor 2 - NRG1663851 NRG1663851
Anti-Neurotensin Receptor 2 -2547201 2547201
Anti-Neurotensin Receptor 2 -2556396 2556396
Anti-Neurotensin Receptor 2 -2717652 2717652
Anti-Neurotensin Receptor 2 Polyclonal Antibody 2947639
Anti-Neurotensin Receptor 2 Polyclonal Antibody 2967233
Anti-Neurotensin Receptor 2 Polyclonal Antibody 2955691