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07-829 Sigma-AldrichAnti-phospho-FAK (Tyr407) Antibody

Anti-phospho-FAK (Tyr407) Antibody is an antibody against phospho-FAK (Tyr407) for use in WB.

Anti-phospho-FAK (Tyr407) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: PTK2, pp125FAK, FAK1, FADK, FAK UniProt Number: Q05397

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-829
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-phospho-FAK (Tyr407) Antibody
Alternate Names	PTK2 FADK FAK FAK1 pp125FAK Focal Adhesion Kinase 1

References

Product Information
Format	Affinity Purified

Applications
Application	Anti-phospho-FAK (Tyr407) Antibody is an antibody against phospho-FAK (Tyr407) for use in WB.
Key Applications	Western Blotting
Application Notes	Outside independent labs report it working in immunocytochemistry and immunohistochemistry.

Biological Information
Immunogen	Peptide corresponding to amino acid region encompassing the human, mouse, rat, and chicken phospho-FAK (Tyr407)
Host	Rabbit
Specificity	Recognizes phosphor-FAK (Tyr407)
Isotype	IgG
Species Reactivity	Human
Species Reactivity Note	Predicted to cross-react with Mouse, Rat, and Chicken based on complete sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_005607.3 NM_153831.2
Entrez Gene Summary	This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.
Gene Symbol	PTK2 pp125FAK FAK1 FADK FAK
Modifications	Phosphorylation
Purification Method	ImmunoAffinity Purified
UniProt Number	Q05397
UniProt Summary	FUNCTION: SwissProt: Q05397 # Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. SIZE: 1052 amino acids; 119233 Da SUBUNIT: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with SHB (By similarity). Interacts with TGFB1I1. SUBCELLULAR LOCATION: Cell junction, focal adhesion; Cytoplasmic side. Note=Constituent of focal adhesions. TISSUE SPECIFICITY: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain. DOMAIN: SwissProt: Q05397 The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity). & The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions. PTM: Phosphorylated on 6 tyrosine residues upon activation. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain.
Molecular Weight	125 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunoblot.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	2 years at -20°C

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade ITEM Number
产品目录编号	GTIN
07-829	04053252676536

Documentation

Anti-phospho-FAK (Tyr407) Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho-FAK (Tyr407) Antibody 分析证书

标题	批号
Anti-phospho-FAK (Tyr407) (Affinity purified Rabbit polyclonal IgG) - NG1944007	NG1944007
anti-phospho-FAK (Tyr407) - 0605030964	0605030964

参考

参考概述	公共医疗ID
Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities Le Boeuf, Fabrice, et al J Biol Chem, 279:39175-85 (2004) 2004	15247219
Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407 Matkowskyj, Kristina A, et al J Histochem Cytochem, 51:1041-8 (2003) 2003	12871985

Related Products

产品目录编号	描述
05-1139	Anti-Focal Adhesion Kinase Antibody, clone BLAb2H7
05-1140	Anti-phospho-Focal Adhesion Kinase (Tyr397) Antibody, clone 18
05-182	Anti-FAK Antibody, clone 2A7
05-537	Anti-FAK Antibody, clone 4.47
06-543	Anti-FAK Antibody
07-832	Anti-phospho-FAK (Tyr861) Antibody
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16-233	Anti-FAK Antibody, clone 4.47, Alexa Fluor® 488 conjugate
16-234	Anti-FAK Antibody, clone 4.47, Alexa Fluor® 555 conjugate
ABT135	Anti-phospho-FAK (Tyr397) Antibody

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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