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287840 Sigma-AldrichDiclofenac Sodium - CAS 15307-79-6 - Calbiochem

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

Primary Target: COX-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
15307-79-6	C₁₄H₁₀Cl₂NO₂ · Na

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产品目录编号	包装	数量 / 包装
287840-1GMCN		1 gm	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC₅₀ = 9.5 µM).
Catalogue Number	287840
Brand Family	Calbiochem®
Synonyms	2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

References
References	Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res. 45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

Product Information
CAS number	15307-79-6
ATP Competitive	N
Form	White solid
Hill Formula	C₁₄H₁₀Cl₂NO₂ · Na
Chemical formula	C₁₄H₁₀Cl₂NO₂ · Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Segment	MQ100

Applications

Biological Information
Primary Target	COX-1
Primary Target IC<sub>50</sub>	60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	AG6330000

Safety Information
R Phrase	R: 23/24/25-63 Toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.
S Phrase	S: 22-36 Do not breathe dust. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade ITEM Number
产品目录编号	GTIN
287840-1GMCN	04055977197877

Documentation

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem 分析证书

标题	批号
287840	输入批号

参考

参考信息概述
Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res. 45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

小册子

标题
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数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-April-2008 RFH
Synonyms	2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
Description	A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC₅₀ = 76 nM) and COX-2 (IC₅₀ = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC₅₀ ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
Form	White solid
CAS number	15307-79-6
RTECS	AG6330000
Chemical formula	C₁₄H₁₀Cl₂NO₂ · Na
Structure formula
Purity	≥98% by TLC
Solubility	H₂O (25 mg/ml)
Storage	+15°C to +30°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 3081
References	Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res. 45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Amyloidogenesis Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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