566330 Sigma-AldrichSIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem
The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII
Recommended Products
概述
| Replacement Information |
|---|
重要规格表
| CAS # | Empirical Formula |
|---|---|
| 1105698-15-4 | C₂₆H₂₂N₂O₂ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 566330-10MGCN | 塑胶安瓿;塑胶针药瓶 | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures. |
| Catalogue Number | 566330 |
| Brand Family | Calbiochem® |
| Synonyms | N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII |
| References | |
|---|---|
| References | Lara, E., et al. 2009. Oncogene 28, 781. |
| Product Information | |
|---|---|
| CAS number | 1105698-15-4 |
| Form | Yellow solid |
| Hill Formula | C₂₆H₂₂N₂O₂ |
| Chemical formula | C₂₆H₂₂N₂O₂ |
| Structure formula Image | |
| Quality Segment | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade ITEM Number | |
|---|---|
| 产品目录编号 | GTIN |
| 566330-10MGCN | 04055977191462 |
Documentation
SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem MSDS
| 职位 |
|---|
SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem 分析证书
| 标题 | 批号 |
|---|---|
| 566330 |
参考
| 参考信息概述 |
|---|
| Lara, E., et al. 2009. Oncogene 28, 781. |
数据表
| 标题 |
|---|
| SIRTainty™ Class III HDAC Assay |