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T11100P

DMT-dT Pharmadite®

Synonym(s):

5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-dT Phosphoramidite

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About This Item

Empirical Formula (Hill Notation):
C40H49N4O8P
CAS Number:
98796-51-1
Molecular Weight:
744.81
NACRES:
NA.51
PubChem Substance ID:
329826643
UNSPSC Code:
41116107
MDL number:
MFCD00055063
Assay:
≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)
Biological source:
non-animal source (no BSE/TSE risk)
Form:
powder or granules
Solubility:
soluble, clear
Storage temp.:
2-8°C
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biological source

non-animal source (no BSE/TSE risk)

Quality Segment

300

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

>= 170ppm, none detected (S/N <2.5), ≤0.1% single unspecified Imprity (reversed phase HPLC), ≤0.3% P(III) 100-169ppm (31P-NMR), ≤0.3% dT2 (reversed phase HPLC, DMT-dT cyanoethyl-H-posphonate), ≤0.3% dT3 (reversed phase HPLC, DMT-dT phosphoramidate), ≤0.30 wt. % water content (Karl Fischer), ≤0.5% P(V) -25-99ppm (31P-NMR), ≤3.0 wt. % residual solvent content

color

white to off-white

solubility

soluble, clear

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: deoxythymidine
base protecting group: none
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=C(C)C(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-35-24-37(43-25-29(5)38(45)42-39(43)46)51-36(35)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,53?/m0/s1

InChI key

UNOTXUFIWPRZJX-CEXSRUIHSA-N

General description

DMT-dT Pharmadite® is a Pharmadite® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity.Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free fromcontaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remainingimpurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Legal Information

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

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