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A4393

R-(−)-Apomorphine hydrochloride hemihydrate

Name: <I>R</I>-(−)-Apomorphine hydrochloride hemihydrate
Brand: SIGMA

calcined, ≥98% (with NaOH, titration)

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Fórmula lineal:

C₁₇H₁₇NO₂ · HCl · 1/2H₂O

Número CAS:

41372-20-7

Peso molecular:

312.79

NACRES:

NA.77

PubChem Substance ID:

24278821

UNSPSC Code:

12352210

EC Number:

206-243-0

MDL number:

MFCD00150904

Assay:

≥98% (with NaOH, titration)

Form:

calcined, (Powder to Crystalline Powder)

Storage condition:

protect from light, under inert gas

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Propiedades

Quality Segment

200

assay

≥98% (with NaOH, titration)

form

calcined, (Powder to Crystalline Powder)

storage condition

protect from light, under inert gas

color

white to gray

mp

285-287 °C (lit.)

solubility

H₂O: ~10 mg/mL, clear, yellow-green

SMILES string

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1

InChI key

CXWQXGNFZLHLHQ-DPFCLETOSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Descripción

Application

R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.

Biochem/physiol Actions

R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c