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D1159

Dexamethasone 21-phosphate disodium salt

Name: Dexamethasone 21-phosphate disodium salt
Brand: SIGMA

≥98%, Glucocorticoid , powder

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₈FNa₂O₈P

CAS Number:

2392-39-4

Molecular Weight:

516.40

NACRES:

NA.25

PubChem Substance ID:

24893369

UNSPSC Code:

51422340

EC Number:

219-243-0

MDL number:

MFCD00079105

Beilstein/REAXYS Number:

6473066

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Properties

Product Name

Dexamethasone 21-phosphate disodium salt, ≥98%

Quality Level

100

assay

≥98%

form

powder

impurities

≤1% ethanol

color

white to off-white

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI key

PLCQGRYPOISRTQ-FCJDYXGNSA-L

Gene Information

human ... NR3C1(2908)

Description

Application

Dexamethasone 21-phosphate disodium salt has been used:

as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models
as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice
to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Biochem/physiol Actions

Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes. It exhibits therapeutic effects against cystic fibrosis and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.