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36-014 Anti-phospho-FKHR (Ser329) Antibody

Detect phospho-FKHR (Ser329) with Anti-phospho-FKHR (Ser329) Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.

Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: FOXO1, FKHR, FKH1, FOXO1A UniProt Number: Q12778
36-014
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number36-014
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-FKHR (Ser329) Antibody
      References
      Product Information
      FormatAffinity Purified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
      Applications
      ApplicationDetect phospho-FKHR (Ser329) with Anti-phospho-FKHR (Ser329) Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids surrounding phosphorylated Ser329 of human FKHR
      HostRabbit
      SpecificityGST-FKHR phosphorylated on serine 329
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
      Gene Symbol
      • FOXO1
      • FKHR
      • FKH1
      • FOXO1A
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12778 # Transcription factor.
      SIZE: 655 amino acids; 69662 Da
      SUBUNIT: Interacts with LRPPRC (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
      TISSUE SPECIFICITY: Ubiquitous.
      PTM: Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Thr-24, Ser-256 and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser- 329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE: SwissProt: Q12778 # Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.
      SIMILARITY: SwissProt: Q12778 ## Contains 1 fork-head DNA-binding domain.
      Molecular Weight70 - 80 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on FKHR fusion protein (Catalog #14-343) phosphorylated with active Akt1/PKBα (Catalog #14-276)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      36-014 04053252279379

      Documentation

      Verwandte Produkte & Anwendungen

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies