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616520 TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem

The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications.

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Synonyme: 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      946387-07-1C₁₄H₂₂Cl₂N2O₂S
      Description
      OverviewA cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 µM).
      Catalogue Number616520
      Brand Family Calbiochem®
      Synonyms2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734
      References
      ReferencesVincent, F., et al. 2009. Biochem. Biophys. Res. Commun. 389, 490.
      Product Information
      CAS number946387-07-1
      FormYellow solid
      Hill FormulaC₁₄H₂₂Cl₂N2O₂S
      Chemical formulaC₁₄H₂₂Cl₂N2O₂S
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Bestellnummer GTIN
      616520 0

      Documentation

      TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      616520

      Literatur

      Übersicht
      Vincent, F., et al. 2009. Biochem. Biophys. Res. Commun. 389, 490.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-October-2012 JSW
      Synonyms2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734
      DescriptionA cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number946387-07-1
      Chemical formulaC₁₄H₂₂Cl₂N2O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesVincent, F., et al. 2009. Biochem. Biophys. Res. Commun. 389, 490.