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07-2115 Anti-phospho-RSK4 Antibody (Ser372)

This phospho-RSK4 antibody is validated for use in WB for the detection of the phospho-RSK4 protein.

Anti-phospho-RSK4 Antibody (Ser372) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: PP90RSK4, RSK-4, RSK4, pp90RSK4 UniProt Number: Q9UK32
07-2115
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2115
      DescriptionAnti-phospho-RSK4 Antibody (Ser372)
      Alternate Names
      • 90 kDa ribosomal protein S6 kinase 6
      • Ribosomal S6 kinase 4
      • S6K-alpha 6
      • p90-RSK 6
      • ribosomal protein S6 kinase polypeptide 6
      • ribosomal protein S6 kinase, 90kD, polypeptide 6
      • ribosomal protein S6 kinase, 90kDa, polypeptide 6
      Background InformationRSK1, RSK2, RSK3, and RSK4 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases. Ribosomal S6-kinase 4 (RSK4) is thought to be mapped in the critical region that is commonly deleted in X-linked deafness type 3, mental retardation, and choroideremia. It may be involved in normal neuronal development. RSK4 is also thought to play a role in non-growth factor signaling and may also be important in tumor suppression.
      References
      Product Information
      FormatAffinity Purified
      Control
      • EGF treated and untreated PC-12 cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis phospho-RSK4 antibody is validated for use in WB for the detection of the phospho-RSK4 protein.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human RSK4 phosphorylated at Ser372.
      EpitopePhosphorylated Ser372
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes RSK4 phosphorylated at Ser372.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
      Gene Symbol
      • PP90RSK4
      • RSK-4
      • RSK4
      • pp90RSK4
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      COFACTOR: Magnesium (By similarity).

      ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues (By similarity).

      SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).

      PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

      Contains 1 AGC-kinase C-terminal domain.

      Contains 2 protein kinase domains.
      Molecular Weight ~80 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in EGF treated and untreated PC-12 cell lysates.

      Western Blot Analysis: 2 µg/mL of this antibody detected RSK4 on 10 µg of EGF treated and untreated PC-12 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      07-2115 04053252292125

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies