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GF346 TGF-β1,
Human Recombinant Animal Free

TGF-β1,
Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01137
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GF346
10µg  
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      Overview

      Replacement Information

      Key Spec Table

      SourcePurity
      CHO cellsProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Description
      Catalogue NumberGF346
      DescriptionTGF-β1,
      Human Recombinant Animal Free
      Alternate Names
      • TGFb1
      • TGFbI
      • TGFB
      • Transforming Growth Factor-β1
      Background InformationThe three mammalian isoforms of TGF-β (TGF-β1, TGF-β2, TGF-β3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF- isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors.

      Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
      References
      Product Information
      PresentationProduct is presented without additives and is filtered through a 0.2 micron filter before lyophilization
      Quality SegmentMQ100
      Applications
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceCHO cells
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceDetermined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size10µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      GF346 04053252979057

      Documentation

      TGF-β1,
      Human Recombinant Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      TGF-β1,
      Human Recombinant Animal Free Certificates of Analysis

      TitleLot Number
      TGF-β1, Human Recombinant Animal Free 2898459
      TGF-β1, Human Recombinant Animal Free 3075618
      TGF-β1, Human Recombinant Animal Free 2586834
      TGF-β1, Human Recombinant Animal Free Q2436474
      TGF-β1, Human Recombinant Animal Free 2582331
      TGF-β1, Human Recombinant Animal Free 2620658
      TGF-β1, Human Recombinant Animal Free 2886936
      TGF-β1, Human Recombinant Animal Free 2653155
      TGF-β1, Human Recombinant Animal Free 2799118
      TGF-β1, Human Recombinant Animal Free 3052619
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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors