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565788 β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1).

β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: BACE Inhibitor C3

Primary Target: BACE-1 human
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565788
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
797035-11-1C₃₁H₃₈N₄O₅S

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565788-1MG
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      Description
      OverviewA cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number565788
      Brand Family Calbiochem®
      SynonymsBACE Inhibitor C3
      References
      ReferencesHalima, S.B., et al. 2016. Cell Reports. 14, In press.
      Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
      Product Information
      CAS number797035-11-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₁H₃₈N₄O₅S
      Chemical formulaC₃₁H₃₈N₄O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Application CommentsSolubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.
      Biological Information
      Primary TargetBACE-1 human
      Primary Target IC<sub>50</sub>15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      565788-1MG 04055977191820

      Documentation

      β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      565788

      Références bibliographiques

      Aperçu de la référence bibliographique
      Halima, S.B., et al. 2016. Cell Reports. 14, In press.
      Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2014 JSW
      SynonymsBACE Inhibitor C3
      DescriptionA cell-permeable and potent inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 230 nM, 7.6 µM and > 50 µM for BACE-2, cathepsin D, and renin, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number797035-11-1
      Chemical formulaC₃₁H₃₈N₄O₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      CommentsSolubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHalima, S.B., et al. 2016. Cell Reports. 14, In press.
      Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.