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370698 GW7647 - CAS 265129-71-3 - Calbiochem

A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPARα.

GW7647 - CAS 265129-71-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: GW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III

Primary Target: PPARα
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370698
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Tableau de caractéristiques principal

CAS #Empirical Formula
265129-71-3C₂₉H₄₆N₂O₃S

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370698-5MG
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      Description
      OverviewA cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.
      Catalogue Number370698
      Brand Family Calbiochem®
      SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
      References
      ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
      Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
      Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
      Poirier, H., et al. 2001. Biochem. J. 355, 481.
      Product Information
      CAS number265129-71-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₄₆N₂O₃S
      Chemical formulaC₂₉H₄₆N₂O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetPPARα
      Primary Target IC<sub>50</sub>EC50 = 6 nM, 1.1 µM and 6.2 µM for human PPARα, γ and δ, respectively; EC50 = 1 nM, 1.3 µM and 2.9 µM for murine PPARα, γ and δ, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      370698-5MG 04055977191769

      Documentation

      GW7647 - CAS 265129-71-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GW7647 - CAS 265129-71-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      370698

      Références bibliographiques

      Aperçu de la référence bibliographique
      Muoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
      Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
      Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
      Poirier, H., et al. 2001. Biochem. J. 355, 481.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
      DescriptionA cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 6 nM for human PPARα, 1.1 µM for human PPARγ, and 6.2 µM human PPARδ; 1 nM for murine PPARα, 1.3 µM for murine PPARγ, and 2.9 µM murine PPARδ). Also shown to lower lipid levels in rats.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number265129-71-3
      Chemical formulaC₂₉H₄₆N₂O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (12 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
      Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
      Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
      Poirier, H., et al. 2001. Biochem. J. 355, 481.