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No deben combinarse los siguientes MAPmates™: -MAPmates™ que requieren un tampón de ensayo diferente. -Pares MAPmate™ fosfoespecíficos y totales, por ejemplo, GSK3β y GSK3β (Ser 9). -MAPmates™ con panTyr y específicos de sitio; por ejemplo, receptor del fosfo-EGF y fosfo-STAT1 (Tyr701). -Más de 1 fosfo-MAPmate™ para una sola diana (Akt, STAT3). -La GAPDH y la β-tubulina no pueden combinarse con kits o MAPmates™ que contengan panTyr.
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Supply Program Supply Robustness and Control. Stay Ahead.
Mega-trends are contributing to a boom in the biopharmaceutical industry. Biopharmaceutical manufacturers are accelerating drug development, optimizing productivity and investing in manufacturing capacity globally.
As a leading partner and supplier to the industry, we strengthen our supply chain to support our commitment of on-time delivery reliability and product quality to help you stay ahead.
Learn more on the drivers of growth in the industry, and their impact on the supply chain risks.
This report from the Economist Intelligence Unit explores the growth strategies of global pharmaceutical companies and their plans for managing associated risks.
To help you keep pace with this growth trajectory and minimize risk, our Supply Robustness and Control program depends upon a disciplined approach including:
Supply Chain Reliability
The routine, reliable supply of the right high-quality products in the right place at the right time through demand planning, material/supplier management, production planning, manufacturing to inventory management, warehousing, distribution, and logistics.
Supply Chain Risk Management
The proactive identification and implementation of mitigation decisions through capacity planning, business continuity planning, change management, supplier risk management, supply chain mapping, disaster recovery planning and more.
The ongoing programs to ensure quality and compliance, such as in-process testing, lot release testing, process characterization and control, ISO certifications and more.
Transparency of Information
The easy access to information via our Emprove® suite, labeling, documentation, website, and a global team of customer service and technical service experts.
We are grateful to have been recognized for our robust and resilient supply chain.
Best Bioprocessing Supplier in Asia
For second consecutive year, Merck chosen as "Best Bioprocessing Supplier" by Asia-Pacific Bioprocessing Excellence Awards. Merck also wins "Best Bioprocessing Supplier" Award for Single-use Systems.
The Global Supply Chain Resiliency Council (GSCRC) named Merck the Resilient Supply Chain Collaborator of the Year for effective collaboration with customers to achieve improved risk transparency throughout our supply chain.
Read the series of articles from The Medicine Maker
The Transformation to Excellence
How a customer-focused mission to boost single-use assembly product quality and supply security led to the Mobius® MyWay Program and a manufacturing site transformation.
Single-use, Your Way
Disposable technologies are expected to see even greater demand in the future – and that puts pressure on suppliers to up their game in terms of lead times. See how we are doing it.
Single-use That’s Ready When You Are
With a growing number of components and highly customized assemblies, the supply chain for single-use becomes quite complex. Merck has designed a new program offering customized single-use assemblies with reduced lead times, and an enhanced level of supply security.
Globalization of Single Use
Learn more on the rapid rise of single-use systems, and explore their role in the biomanufacturing facility of the future.
Explore More: Mobius® MyWay
The Mobius® MyWay Program is a three-tiered offering that introduces a novel approach to single-use standardization, designed to help biopharmaceutical manufacturers implement flexible manufacturing with greater speed and enhanced supply security.
Mobius® Stock
Mobius® Select
Mobius® Choice
Mobius® Stock
On-demand repeat assemblies, ready in just 24 hours.
The reliable supply of products depends upon close collaboration with our customers and a disciplined approach to supply chain management. In addition to demand planning and forecasting, other factors include procurement, material/supplier management, inventory management, manufacturing, warehousing, distribution and logistics. We strategically invest in capacity expansions and supply chain innovations to enable us to improve on-time delivery reliability and product quality.
We have numerous production sites and distribution centers around the world; supporting our commitment to deliver the right products in the right place at the right time.
Our sales and operations planning process informs inventory replenishment plans and distribution requirements. A key element of our success is establishing and maintaining close relationships with our customers and suppliers.
Learn more on how collaborative forecasting helps minimize supply chain disruption:
Our supplier quality management program controls the quality of all procured products, processes and services that directly or indirectly support material provided to our customers.
We categorize suppliers as critical, essential and non-critical and use this to determine assessment frequency and method, including audits. Our process considers the complexity of technology, sites impacted, country of origin, compliance and corporate social responsibility, demand and more.
Emprove® Program Highlights
Our Emprove® program facilitates risk assessment and provides assistance in developing more robust processes. The program offers comprehensive and thorough documentation of our filters and single-use components as well as pharmaceutical raw and starting materials.
Robust materials management, supplier quality management, quality control, and business continuity planning are essential to ensure continuous supply of single-use bags.
Good Distribution Practices (GDP) ensure that the level of quality determined by good manufacturing processes (GMP) is maintained throughout the distribution network. Following these practices, products are consistently stored, transported and handled under appropriate conditions as required by the Marketing Authorization (MA) or product specification.
Product labels for pharma raw and starting materials, as well as for filters, feature a 2D Data Matrix GS1 barcode, a seamless access to essential product information.
As supply chains become increasingly complex, collaboration between biopharmaceutical customers and suppliers is crucial for supply continuity and control.
Rapid growth and geographic expansion in the biopharmaceutical market increase supply chain complexity and the risk of supply disruptions. To minimize the probability of a supply chain disruption we identify and reduce risks through a multi-faceted approach which includes:
Business Continuity Planning (BCP) and Disaster Recovery Planning (DRS)
Supplier risk management
Supply chain mapping
Business Continuity and Disaster Recovery Planning
Business continuity planning includes identifying, preventing, mitigating, and responding to supply risks as well as disaster recovery planning.
Supply Chain Business Continuity Bob McGuirck, Head of Process Solutions Supply Chain
Learn more on how this multi-faceted approach helps minimize the likehood and impact of supply disruption.
Our long-term business continuity plan focuses on the continuous improvement of the safety, quality and consistency of industrial cell culture media supply.
Merck applies a holistic approach in the evaluation of potential supply risks; processes for business continuity follow pre-defined, formally documented protocols.
Robust materials management, supplier quality management, quality control, and business continuity planning are essential to ensure continuous supply of single-use bags.
To ensure the highest quality and minimize disruption to supply, we work closely with all members of our global network of suppliers to identify, assess and control threats. We remain vigilant about quality, regulatory compliance, financials, possible mergers and acquisitions as well as natural disasters and geopolitical changes that might impact our supply chain.
Supply chain mapping documents the source of materials, storage, transportation and distribution of products. This process enables transparency throughout the supply chain, provides insights into vulnerabilities, potential risks and allows for development and implementation of proactive mitigation strategies.
Emprove® Program Highlights
Increasing Supply Chain Transparency with the Emprove® Program
Our Emprove® program facilitates your risk assessment and provides assistance in developing more robust processes. The program offers comprehensive and thorough documentation of our filters and single-use components as well as pharmaceutical raw and starting materials. It not only covers the latest regulatory requirements, but also anticipates industry expectations not yet covered by regulation.
Our quality control and regulatory program consists of a quality management system, processes and procedures to ensure the quality of raw materials and effectively control, manage and communicate changes we initiate related to products and services.
Quality Management System
We use ISO 9001:2015 as the basis for our Quality Management System. Sites that manufacture medical devices are also certified to ISO 13485. We also follow good manufacturing practices (GMP) and additional quality management guidelines including:
U.S. Food and Drug Administration - Code of Federal Regulations Title 21
Our processes and procedures ensure our supply chain partners are adhering to the same quality standards for which Merck is known and our customers trust.
Our Emprove® program facilitates your risk assessment and provides assistance in developing more robust processes. The program offers comprehensive and thorough documentation of our filters and single-use components as well as pharmaceutical raw and starting materials.
Assurance of Supply, Biopharm International
Robust materials management, supplier quality management, quality control, and business continuity planning are essential to ensure continuous supply of single-use bags.
Managing Quality in Single-use Systems, Biopharm International
Regulatory expectations for the qualification of single-use systems, extractables and leachables
Supplier-initiated changes create risks for biopharmaceutical manufacturers that can impact drug product quality, safety, efficacy, and security of supply to patients. We are committed to controlling, managing and communicating changes in the most stringent manner to ensure security of your supply.
Filter Highlights
In this webinar, we provide an overview of our change control process for critical raw materials used in our sterilizing grade filters.
Robust materials management, supplier quality management, quality control, and business continuity planning are essential to ensure continuous supply of single-use bags.
Supply Chain Change Management Dawn MacNeill, Marketing Operations Manager
Learn how effective supplier change management can reduce your efforts to assess and accept changes, and the key components of an effective change management program.
Transparency of Information Information and Support: When and Where you Need It
We are committed to providing you with the right information at the right time to support our products and services. Our global service and support organizations and innovative Emprove® suite of dossiers help ensure your success.
Customer Quality Management
Our mission is to support customers with accurate, timely and value-added responses to concerns and issues.
Merck offers a range of eCommerce solutions designed to meet your research, evaluation, customer service, technical support, and purchasing needs. Our goal is to empower your organization to find, select, and purchase quickly and efficiently.
Getting the information you need on our portfolio of raw materials, filters and single-use components is more convenient than ever. Our Emprove® suite is an online resource allowing you to find dossiers you need at any time of day or night. The suite is constantly updated and optimized to ensure easy searching. Subscribe today and get immediate, online access to dossiers representing the entire Emprove® portfolio for two years.
