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SCT093 BioTracker Mito-Chloride Live Cell Dye

Fluorescent probe for monitoring Cl- in mitochondria.

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SCT093
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT093
      DescriptionBioTracker Mito-Chloride Live Cell Dye
      OverviewMitochondrial membranes contain several ion channels. Among them, mitochondrial chloride channels are involved in the regulation of the mitochondrial volume, maintenance of the mitochondria membrane potential, and apoptosis. The chloride transport activity of these channels is known to be dependent on the mitochondrial pH, with their activity increasing under acidic conditions and decreasing at pH greater than 7.0 (1).

      BioTracker Mito-Chloride Live Cell Dye is a mitochondrial Cl- selective fluorescent probe. Fluorescence of probe is insensitive to pH over the physiological pH range and is quenched by Cl- with Stern−Volmer quenching constant of 201 M−1 at pH 7.0 (1). This probe can be used to monitor the effects of substances on chloride levels in mitochondria.

      Reference:
      1. Park, Sang-Hyun, et al. "Mitochondrial Cl–-Selective Fluorescent Probe for Biological Applications." Analytical Chemistry 92.18 (2020): 12116-12119.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Yellow solid.
      Applications
      ApplicationFluorescent probe for monitoring Cl- in mitochondria.
      Biological Information
      Molecular Weight498.41
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, desiccate and protect from light.
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      SCT093 04065265944472

      Documentation