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07-815 Sigma-AldrichAnti-phospho-Raf-1 (Tyr340/Tyr341) Antibody

Detect phospho-Raf-1 (Tyr340/Tyr341) using this Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody validated for use in WB.

Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: RAF1, C-RAF, cRaf, Raf-1, c-Raf, CRAF, RAF UniProt Number: P04049

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-815
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody
Alternate Names	CRAF Raf1 c-Raf

References

Product Information
Format	Affinity Purified

Applications
Application	Detect phospho-Raf-1 (Tyr340/Tyr341) using this Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody validated for use in WB.
Key Applications	Western Blotting
Application Notes	Predicted to cross-react with Mouse and Rat based on complete sequence homology.

Biological Information
Immunogen	Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Raf-1 (Tyr340/341).
Host	Rabbit
Specificity	Recognizes phospho-Raf-1 (Tyr340/341)
Isotype	IgG
Species Reactivity	Human
Species Reactivity Note	Predicted to cross-react with Mouse and Rat based on complete sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002880.2
Entrez Gene Summary	Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text]
Gene Symbol	RAF1 C-RAF cRaf Raf-1 c-Raf CRAF RAF
Modifications	Phosphorylation
Purification Method	ImmunoAffinity Purified
UniProt Number	P04049
UniProt Summary	FUNCTION: SwissProt: P04049 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3. COFACTOR: Binds 2 zinc ions per subunit. SIZE: 648 amino acids; 73052 Da SUBUNIT: Interacts with Ras proteins. The interaction with Ras is antagonized by RIN1. Weakly interacts with RIT1 (By similarity). Interacts with STK3, which inhibits its pro-apoptotic activity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY:SwissProt: P04049 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain.
Molecular Weight	74 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunoblot.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	2 years at -20°C

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade ITEM Number
产品目录编号	GTIN
07-815	04053252369018

Documentation

Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho-Raf-1 (Tyr340/Tyr341) Antibody 分析证书

标题	批号
Anti-phospho-Raf-1 (Tyr340/341) - 2013514	2013514
Anti-phospho-Raf-1 (Tyr340/341) (Affinity purified Rabbit polyclonal IgG) - 2386934	2386934
Anti-phospho-Raf-1 (Tyr340/341) (Affinity purified Rabbit polyclonal IgG) - 2159616	2159616
Anti-phospho-Raf-1 (Tyr340/341) (Affinity purified Rabbit polyclonal IgG) - DAM1798675	DAM1798675
Anti-phospho-Raf-1 (Tyr340/341) (Affinity purified Rabbit polyclonal IgG) - NG1926736	NG1926736
Anti-phospho-Raf-1 (Tyr340/341) - 1982452	1982452
Anti-phospho-Raf-1 (Tyr340/341) - DAM1411305	DAM1411305
Anti-phospho-Raf-1 (Tyr340/341) - DAM1498501	DAM1498501
Anti-phospho-Raf-1 (Tyr340/341) - DAM1717402	DAM1717402
Anti-phospho-Raf-1 (Tyr340/341) - JBC1863390	JBC1863390

参考

参考概述	公共医疗ID
Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites Hekman, Mirko, et al J Biol Chem, 279:14074-86 (2004) 2004	14688280
Positive and negative regulation of Raf kinase activity and function by phosphorylation Chong, H, et al EMBO J, 20:3716-27 (2001) 2001	11447113

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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