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382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator

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      概述

      Replacement Information

      重要规格表

      CAS #Empirical Formula
      451491-47-7C₁₆H₁₃ClF₃NO₂
      Description
      OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
      Catalogue Number382120
      Brand Family Calbiochem®
      SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
      References
      ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
      Product Information
      CAS number451491-47-7
      FormOff-white solid
      Hill FormulaC₁₆H₁₃ClF₃NO₂
      Chemical formulaC₁₆H₁₃ClF₃NO₂
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      产品目录编号 GTIN
      382120 0

      Documentation

      Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem 分析证书

      标题批号
      382120

      参考

      参考信息概述
      Mantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2017 JSW
      SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
      DescriptionA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number451491-47-7
      Chemical formulaC₁₆H₁₃ClF₃NO₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityEthanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.