434610 Sigma-AldrichLeukadherin-1 - CAS 344897-95-6 - Calbiochem
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.
More>> A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Less<<Leukadherin-1 - CAS 344897-95-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 344897-95-6 | C₂₂H₁₅NO₄S₂ |
| Description | |
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| Overview | A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. |
| Catalogue Number | 434610 |
| Brand Family | Calbiochem® |
| Synonyms | LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II |
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| References | Maiguel, D., et al. 2011. Sci. Signal. 4, ra57. |
| Product Information | |
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| CAS number | 344897-95-6 |
| Form | Red-brown solid |
| Hill Formula | C₂₂H₁₅NO₄S₂ |
| Chemical formula | C₂₂H₁₅NO₄S₂ |
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| Quality Segment | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| 产品目录编号 | GTIN |
| 434610 | 0 |
Documentation
Leukadherin-1 - CAS 344897-95-6 - Calbiochem MSDS
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Leukadherin-1 - CAS 344897-95-6 - Calbiochem 分析证书
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| 434610 |
参考
| 参考信息概述 |
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| Maiguel, D., et al. 2011. Sci. Signal. 4, ra57. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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