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04-962 Anti-Interleukin 12 (IL-12) Antibody, clone 17.8

Anti-Interleukin 12 (IL-12) Antibody, clone 17.8 is an antibody against Interleukin 12 (IL-12) for use in FC.

Anti-Interleukin 12 (IL-12) Antibody, clone 17.8 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 UniProt Number: P43432
04-962
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-962
      DescriptionAnti-Interleukin 12 (IL-12) Antibody, clone 17.8
      Alternate Names
      • CLMF p40
      • Cytotoxic lymphocyte maturation factor 40 kDa subunit
      • IL-12 subunit p40
      • IL12, subunit p40
      • NK cell stimulatory factor chain 2
      • interleukin 12, p40
      • interleukin 12B
      • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
      • interleukin-12 beta chain
      • natural killer cell stimulatory factor, 40 kD subunit
      Background InformationInterleukin 12 (IL-12) is an interleukin produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) and is involved in the differentiation of naive T cells into Th1 cells or Th2 cells. IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits and is considered a T cell stimulating factor. IL-12 stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T and natural killer (NK) cells and reduces IL-4 mediated suppression of IFN-γ. IL-12 can also block the formation of new blood vessels through its induction cascade and is a possible target for anti-cancer drug screening. IL-12 may play a role in autoimmunity by worsening the autoimmune response, due to its key role in induction of Th1 immune responses. Whereas, IL-12 gene knock-out in mice or a treatment of mice with IL-12 specific antibodies seems to ameliorate the diseases.
      References
      Product Information
      FormatPurified
      Control
      • MiCK-3 Cytokine Positive Cells
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Interleukin 12 (IL-12) Antibody, clone 17.8 is an antibody against Interleukin 12 (IL-12) for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse IL-12.
      EpitopeUnknown
      Clone17.8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThis antibody recognizes IL-12.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL12B
      • CLMF
      • CLMF2
      • IL-12B
      • NKSF
      • NKSF2
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC By similarity.

      Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

      SUBUNIT STRUCTURE: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

      SUBCELLULAR LOCATION: Secreted.

      SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 3 subfamily.

      Contains 1 fibronectin type-III domain.

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Molecular Weight ~ 70 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in MiCK-3 Cytokine Positive Cells.

      Flow Cytometry Analysis: A 1:200 dilution of this antibody detected IL-12 in MiCK-3 Cytokine Positive Cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      04-962 04053252626821

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies