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16-217 Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse

Anti-TNF alpha Antibody, clone 3B8, biotin conjugate, mouse is an antibody against TNFα for use in ELISA.

Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: TNF, TNFSF2, Cachectin, cachectin, TNF-alpha, DIF, OTTHUMP00000037669, TNFA, TNF-a UniProt Number: P01375
16-217
200 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISAHtBiotinMonoclonal Antibody
      Description
      Catalogue Number16-217
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TNFα Antibody, clone 3B8, biotin conjugate, mouse
      References
      Product Information
      FormatBiotin
      Applications
      ApplicationAnti-TNF alpha Antibody, clone 3B8, biotin conjugate, mouse is an antibody against TNFα for use in ELISA.
      Key Applications
      • ELISA
      Biological Information
      ImmunogenRecombinant mouse TNFα expressed in E. coli.
      Cloneclone 3B8
      HostHamster
      SpecificityTNFα
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
      Gene Symbol
      • TNF
      • TNFSF2
      • Cachectin
      • cachectin
      • TNF-alpha
      • DIF
      • OTTHUMP00000037669
      • TNFA
      • TNF-a
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
      SIZE: 233 amino acids; 25644 Da
      SUBUNIT: Homotrimer.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted.
      PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
      DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.
      SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by ELISA
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 4°C from date of shipment
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      16-217 04053252272431

      Documentation

      Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse Certificates of Analysis

      TitleLot Number
      Anti-TNFa, clone 3B8, biotin conjugate, mouse - 2204368 2204368
      Anti-TNFalpha;, clone 3B8, biotin conjugate, mouse - 30315 30315
      Anti-TNFα, clone 3B8, biotin conjugate, mouse -2530529 2530529

      References

      Reference overviewPub Med ID
      Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction.
      Muppidi, Jagan R, et al.
      Immunity, 21: 461-5 (2004)  2004

      Show Abstract       		15485624 15485624

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies