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AB15435 Anti-phospho Stargazin (Ser228) Antibody

Anti-phospho Stargazin (Ser228) Antibody is an antibody against phospho Stargazin (Ser228) for use in WB, DB.

Anti-phospho Stargazin (Ser228) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: stargazin UniProt Number: O88602
AB15435
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, H, Eq, OpWB, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15435
      DescriptionAnti-phospho Stargazin (Ser228) Antibody
      Alternate Names
      • calcium channel, voltage-dependent, gamma subunit 2
      • Neuronal voltage-gated calcium channel gamma-2 subunit
      • voltage-dependent calcium channel gamma-2 subunit
      Background InformationStargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-phospho Stargazin (Ser228) Antibody is an antibody against phospho Stargazin (Ser228) for use in WB, DB.
      Key Applications
      • Western Blotting
      • Dot Blot
      Application NotesWestern Blot Analysis: A previous lot of this antibody was successfully used by an independent laboratory in WB. (Susumu Tomita, Ph.D., Department of Cellular and Molecular Physiology, Yale University School of Medicine)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Stargazin at the cytoplasmic domain.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Stargazin at the cytoplasmic domain.
      Species Reactivity
      • Mouse
      • Rat
      • Human
      • Horse
      • Opossum
      Species Reactivity NoteDemonstrated to react with mouse. Predicted to react with rat, human, equine, opossum, marmoset, platypus, and chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • stargazin
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Thought to stabilize the calcium channel in an inactivated (closed) state.

      SUBUNIT STRUCTURE: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.

      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

      TISSUE SPECIFICITY: Brain.

      PTM: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.

      INVOLVEMENT IN DISEASE: Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.

      SEQUENCE SIMILARITIES: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
      Molecular Weight~ 36 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein.

      Dot Blot Analysis: 2 µg/mL of this antibody detected Stargazin in modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB15435 04053252552755

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies