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557403 RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

Primary Target: activity against RNA Polymerase III
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557403
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
577784-91-9C₁₉H₁₅Cl₂N₃O₂S₂

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      Description
      OverviewA cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
      Catalogue Number557403
      Brand Family Calbiochem®
      SynonymsML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
      References
      ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.
      Product Information
      CAS number577784-91-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₁₅Cl₂N₃O₂S₂
      Chemical formulaC₁₉H₁₅Cl₂N₃O₂S₂
      HS Code2935 90 99
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary Targetactivity against RNA Polymerase III
      Primary Target IC<sub>50</sub>27 and 32 µM for Human and S. cerevisiae RNA Pol III
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      557403-10MG 04055977268058

      Documentation

      RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      557403

      References

      Reference overview
      Wu, L., et al. 2003. Euk. Cell 2, 256.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
      DescriptionA cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number577784-91-9
      Chemical formulaC₁₉H₁₅Cl₂N₃O₂S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (15 mg/ml). Slight warming may be necessary to achieve complete solubilization.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.