Amorphous Formulations for Bioavailability Enhancement: Risks and Opportunities

WEBINAR

Solubility is a major challenge in the development of oral solid dosage forms. Amorphous formulation with polymeric solid dispersions has been the technology of choice to enhance solubility. However, this approach may have some downfalls with the ability to successfully stabilize compounds, especially poor glass former compounds with a high propensity to re-crystallize. This webinar will examine amorphous stability from a theoretical perspective in the context of polymeric solid dispersions and mesoporous silica formulations. Finally, recent data demonstrating the potential of mesoporous silica for superior amorphous stabilization of poor glass formers will be presented.

In this webinar, you will learn:

• Why solubility is a critical consideration in the development of oral medication
• How the amorphous form can enhance solubility and increase absorption
• Why some molecules are at risk of re-crystallization with typical polymeric amorphous technologies
• How mesoporous silica can reduce the risk of re-crystallization of poor glass formers